Table 2.
Plasma and tumor pharmacokinetic parameters for Oligo AS
| Tissue | Cmax, μg/ml or g | Tmax, h | T1/2A, h | T1/2β, h | AUC, (μg/ml)⋅h | MRT, h |
|---|---|---|---|---|---|---|
| Plasma | 5.92 (0.83) | 9.93 (2.20) | 3.84 (0.28) | 8.03 (1.50) | 122.07 | 17.13 |
| Tumor | 2.95 (0.45) | 16.34 (4.40) | 3.78 (0.45) | 60.78 (20.10) | 290.92 | 93.15 |
Values are means (and SE) based on the data from three mice at each time point after oral administration of 35S-labeled Oligo AS. Pharmacokinetic parameters were estimated by using a first-order absorption one-compartment model. Cmax, maximal concentration; Tmax, the time of maximal concentration; T1/2A, absorption half-life; T1/2β, elimination half-life; AUC, area under the concentration–time curve; MRT, mean residue time.