Table 1.

Inhibition of anchorage-independent growth of N-Ras(V13)-transformed Rat-1 cells by FTS

Treatment	No. of colonies (×102)
	Colony size
	<100 mm	100–200 mm	>200 mm
0.1% DMSO	5.3  ±  0.6  [100%]	1.5  ±  0.74  [100%]	0.25  ±  0.2
50 μm FTS	3.1  ±  0.4  [60%]	0.3  ±  0.2  [20%]	0
100 μm FTS	2  ±  0.3  [38%]	0	0

N-Ras(V13)-transformed Rat-1 cells were grown on soft agar with or without the indicated concentrations of FTS for 17 days. The sizes and numbers of colonies in three visual fields of duplicate wells were estimated by using a light microscope attached to an image analyzer (44). The estimated numbers of colonies (±SD) per well represent the means of three independent experiments. The numbers given in brackets represent numbers of colonies as % of the DMSO-treated control.