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ELISPOT analysis of SIV-specific CD4+ T cells from vaccinated macaques. CD4+ T cells from animals immunized with SIVmac239nef (A) or SIVmac239Δ3 (B) were stimulated with autologous antigen-presenting cells pulsed with SIV p55 and IFN-γ-producing cells identified by using ELISPOT analysis. (C) Correlation of SIV p55-CD4+ T cells as assessed by ELISPOT with proliferative responses by using PBMCs isolated from the Δnef- or Δ3-immunized macaques.
