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Reintroduction of DLC1 reverts tumorigenesis. (A) Immunoblots of Ras-driven hepatoma cells infected with control retrovirus (v) or retrovirus expressing DLC1 cDNA. (B) Bioluminescence imaging of in situ liver tumor. Hepatoma cells as in A are transplanted into livers of NCR nu/nu mice and imaged at day 14. (C) Quantification of luciferase signal as in B. Error bars denote SD (n = 3). (D) Bioluminescence and GFP imaging of explanted livers at day 14.
