Figure 1.

(A) The dynamics of viral RNA levels and CD4⁺ T lymphocyte counts during the SHIV_DH12 infection of rhesus macaque 565Z. The arrows indicate the times when anti-human CD8 mAb was administered. (B and C) SHIV_DH12R induces p27 antigenemia and causes rapid CD4⁺ T cell depletion in rhesus macaques. Blood collected at the indicated times from two infected rhesus macaques were fractionated into plasma and cells and levels of p27 and CD4⁺ T lymphocytes, respectively, were determined as described in Methods.