Table 2.
Differences in the actions of some beta-blockers.5
Drug | Lipid solubility | Cardio-selectivity | Partial agonist activity | Membrane-stabilizing activity | Peripheral vasodilatation |
---|---|---|---|---|---|
Atenolol | − | + | − | − | − |
Bisoprolol | + | +++ | − | − | + |
Carvedilol | +++ | − | − | ++ | ++ |
Labetalol | + | − | − | ± | ++ |
Metoprolol | + | + | − | ± | + |
Oxprenolol | + | − | + | + | − |
Practolol | − | ++ | + | − | − |
Propranolol | ++ | − | − | ++ | ± |
Sotalol | − | − | − | − | − |
Timolol | + | − | ± | ± | + |
+ means that the drug has the indicated property, to varying degrees depending on the number of symbols; − means that it does not; ±, it is not clear whether it does.