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Homology model depicting the overlapping catalytic sites of PfCHT1, PgCHT1, and human chitotriosidase complexed with allosamidin (yellow, PfCHT1; blue, PgCHT1; white, human chitotriosidase). The three active sites are almost perfectly superimposable, with the exception of a novel pocket found in PgCHT1, seen at lower right. The models were built by using the structure of hevamine complexed with allosamidin as a template.
