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Spontaneous locomotor activity of CREM-mutant mice (n = 11) and wild-type littermates (n = 11). Locomotor activity was measured at 14:00 on 3 consecutive days. On day 4, locomotor activity was recorded at 9:00, 14:00, 21:00, and 2:00. Values represent mean ± SEM. ★, P < 0.05, ★★, P < 0.01 vs. same group on day 1 (A) or day 4 at 9:00 (B) (Dunnett’s t test); ⋆, P < 0.05, ⋆⋆, P < 0.01, vs. wild-type group at the same time point (one-way ANOVA).
