Number of squares crossed (A and B) and
rears (C and D) in the open field by CREM
mutants (n = 11) and wild-type littermates
(n = 11). The behavioral test was performed at
14:00 on 3 consecutive days. On day 4, animals were exposed to the test
at 9:00 and 21:00, and at 14:00 and 2:00 on day 5 and 6, respectively.
Values represent mean ± SEM. ★, P
< 0.05; ★★, P < 0.01 vs.
same group on day 1 (A and C) or day 4 at
9:00 (B and D) (Dunnett’s
t test); ⋆, P < 0.05;
vs. wild-type group at the same time point (one-way ANOVA).