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Anatomy of the suprachiasmatic nuclei in wild-type and CREM mutants. (Upper) Comparative histological sections showing no apparent anatomical alteration in the SCN. Several serial sections were analyzed. Only representative results are shown. (Lower) Inducibility of c-fos 30 min after a light-pulse (400 lx) is comparable in wild-type and CREM mutants. The kinetics of c-fos-induced expression are equivalent in both animals (not shown).
