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. 1999 Nov 23;96(24):14112–14117. doi: 10.1073/pnas.96.24.14112

Figure 3.

Figure 3

Internalization of AMPARs is induced by glutamate and facilitated by NMDAR activation. (A) Incubation of cells with 10 μM glutamate for 1 min followed by chase incubation in the presence of CNQX and d-APV (APV) induced readily detectable internalization of AMPARs (Middle) compared with untreated cells (Top). Inclusion of d-APV (50 μM) in the pulse incubation strongly inhibited this process (Bottom). (B) Quantitation of the number of internalized AMPAR puncta under these conditions (n = 25 for each group).