Figure 1.

Effects of HU-210 (10 ng/g; A), anandamide (4 μg/g; B), and Abn-cbd (20 μg/g; C) in the absence (●) and presence of 3 μg/g SR141716A (○) on mean arterial blood pressure in pentobarbital-anesthetized CB1^+/+ (Left) and CB1^−/− (Right) mice. Mice were injected with a bolus i.v. dose of the indicated agonist at 0 min, 10 min after the injection of vehicle or SR141716A. Points and bars represent means ± SE from 4–7 animals. * indicate significant difference (P < 0.05) from corresponding baseline (0) values.