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. 1997 Nov 25;94(24):12797–12802. doi: 10.1073/pnas.94.24.12797

Figure 1.

Figure 1

Correlation of the log(kcat/Km) and the ratio of ln(kH/kT)/ln(kD/kT) for site-directed mutants of alcohol dehydrogenase. Point A, Val-203 → Gly; point B, Val-203 → Ala:Phe-93 → Trp; point C, Val-203 → Ala; point D, Val-203 → Leu; point E, Phe-93 → Trp; point F, Leu-57 → Phe. Tunneling is indicated when the ratio of ln(kH/kT) to ln(kD/kT) is >3.3 (8).