Table 2.

Function of EpoRs with Altered Stat Signaling in Adult Erythropoiesis^a

Virus	Hematocrit (week)	Spleen weight (g)
None	44 (6)	0.15
SFF-R129C	75 (6)	2.0
	82 (6)	2.2
SFF-R129C/343-S3	82 (8)	0.9
	75 (8)	1.44
	72 (8)	d.b.a.
	No disease	—
SFF-R129C/401-S3	73 (8)	2.2
	74 (8)	3.4
	72 (8)	d.b.a.
	No disease	—
SFF-R129C/343/401-S3	61 (8)	2.2
	55 (8)	1.0
	59 (8)	0.8
	No disease	—

^aAdult mice were infected with recombinant retroviruses as described in Materials and Methods. Blood samples were taken at weekly intervals after infection, and the packed RBC volumes (hematocrits) were measured. Hematocrits for individual animals are shown, with the time of determination (in weeks) indicated. Animals were killed once their hematocrit reached levels of 70–80, or at 8 weeks after infection. Spleens were removed and weighed to determine the extent of splenomegaly. Spleen weights for individual animals are indicated (in grams). Some animals died before analysis of the spleen (d.b.a.).