Figure 8. A structural model for the pore region of TRP channels.
A model of the S5-pore-S6 region of TRPV1 as inspired by the Kv1.2 structure (PDB: 2R9R), prepared with PyMOL software (Delano, 2002). The pore helix is shown in orange. Relative location of the F640 residue is shown in green, and E600 and E648 residues previously implicated in proton modulation are shown in red.