FIG. 1.

Effect of the parenteral and oral administration of the A. suum extract (Ascaris) on the hypernociception and cell influx in ZYA in rats. Rats received the A. suum extract or saline (−) either i.p. (A and B) or p.o. (C and D) 30 min prior to 1 mg zymosan i.a. Naive rats received saline i.a. Articular incapacitation was measured hourly over 4 h as the increase in PET using the rat knee joint incapacitation test. Cell infiltration into joint cavities was assessed 6 h after injection of zymosan. Results show means ± SEM of maximal PET between 3 and 4 h of arthritis (A and C) and means ± SEM of total leukocytes (B and D) (n = 6 animals for each group). Experiments were done three times. *, P < 0.05 compared to control (−) rats.