FIG. 5.

Serum bactericidal antibody responses (1/GMT ± 2 SE) of mice (n = 5 per group) immunized with rfHbp vaccines against strains expressing fHbp in the v.2 or v.3 antigenic group. Strain 8047 expresses fHbp v.2 identical to that of control rfHbp v.2 vaccine. The remaining strains express subvariants of fHbp v.2 or v.3 (Table 2). The data are grouped by JAR 11 (left panel) or JAR 32 (right panel) reactivity. The chimera I and II vaccines are identical except that chimera I is JAR 11 positive and JAR 32 negative, whereas chimera II is JAR 11 negative and JAR 32 positive (see text).