FIG. 7.

A. The number of S. cerevisiae Puf3 and Drosophila Pumilio target genes that have human orthologues and the number of these that are also Pum1 targets in HeLa cells. The statistical significance of this conservation of targets is indicated. B. The motif UGUAHAUA is predominant in yeast Puf3, fly Pumilio, and human Pum1 associated mRNAs, while the proteins encoded by each PUF protein's target mRNAs are not conserved, consistent with the notion of evolutionary rewiring of RNA regulon networks. Data on Puf3 and Pumilio targets were derived from references 17 and 18.