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Model of dual opposing regulatory connections of RASSF1A to cell cycle progression. The presence of RASSF1A provides a regulatory input for the restriction of EWS-dependent cyclin (Cyc) D1 accumulation (antiproliferative) and for the restriction of βTRCP-dependent Emi1 inactivation (proproliferative). Loss of this regulatory input allows aberrant cyclin D1 accumulation but also restricts cyclin A accumulation as a consequence of aberrant APC/C activity during the G1/S phase transition.
