Table 2.
Cosinor Analysis of Male and Female Murine BMSC mRNA Response to Dexamethasone ± Lithium Chloride Exposure (Figure 3)
| Gene | Gender | Period | Acrophase | Acrophase shift | ||
|---|---|---|---|---|---|---|
| Dex | Dex + LiCl | Dex | Dex + LiCl | |||
| Bmal1 | M | 24.4 | 38.7 | 13.1 | 15.6 | 2.5 |
| Bmal1 | F | 24.0 | 27.3 | 13.8 | 16.7 | 2.9 |
| Per3 | M | 26.4 | 35 | 2.4 | 7.1 | 4.7 |
| Per3 | F | 19.3 | 17.9 | 2.0 | 8.9 | 6.9 |
| Rev-erbα | M | 24.2 | 27.5 | 22.9 | 4.1 | 5.2 |
| Rev-erbα | F | 28.3 | 32.4 | 22.6 | 0.9 | 2.3 |
| DBP | M | 22.0 | 27.9 | 2.4 | 5.9 | 3.5 |
| DBP | F | 19.5 | 20.4 | 1.4 | 6.2 | 4.8 |
| Rev-erbβ | M | 24.6 | 29.7 | 0.7 | 5.8 | 5.1 |
| Rev-erbβ | F | 19.8 | 20.2 | 23.9 | 6.2 | 6.3 |
| Mean | M | 24.3±1.6a | 31.8±4.9 a,b | 4.2±1.1 | ||
| Mean | F | 22.2±3.9 | 23.6±6.0b | 4.7±2.0 | ||
Acrophase values are reported based on Circadian Time following dexamethasone exposure. There was a significant difference in the mean period of male BMSCs in the absence and presence of LiCl (a p = 0.009) and between the periods of male and female in the presence of LiCl (b p = 0.044). There was no statistical difference between genders in the period of the dexamethasone alone response nor in the acrophase shift (one tailed Student's t-test).