Table 3.
Cosinor Analysis of Human BMSC mRNA Response to Dexamethasone ± Lithium Chloride Exposure
| Gene | Treatment | Period | P value | Acrophase | Acrophase shift | P value |
|---|---|---|---|---|---|---|
| Bmal1 | Dex | 25.6±1.9 | 0.051 | 14.1±1.1 | 3.6 | 0.002 |
| Bmal1 | Dex/ LiCl | 27.5±0.5 | 17.7±1.5 | |||
| Per3 | Dex | 22.4±1.3 | 0.106 | 2.4±0.5 | 5.7 | 0.001 |
| Per3 | Dex/ LiCl | 21.3±0.7 | 8.1±1.5 | |||
| Rev-erbα | Dex | 24.4±0.1 | 0.050 | 22.5±0.6 | 6.2 | 0.001 |
| Rev-erbα | Dex/ LiCl | 26.0±0.9 | 4.7±1.2 | |||
| DBP | Dex | 21.1±3.6 | 0.227 | 0.9±1.7 | 5.6 | 0.039 |
| DBP | Dex/ LiCl | 18.7±0.9 | 6.5±3.6 | |||
| Rev-erbβ | Dex | 22.8±1.1 | 0.077 | 23.9±1.9 | 4.5 | 0.011 |
| Rev-erbβ | Dex/ LiCl | 24.6±1.9 | 4.4±1.3 | |||
| Mean | Dex | 22.8±1,.2 | 5.0±1.2 | |||
| Dex/LiCl | 23.6±3.6 |
Acrophase values are reported based on Circadian Time following dexamethasone exposure. There was no significantly difference in the mean period length in the absence and presence of LiCl (p = 0.26, one way Student's t-test).