Table 4.

Functional analysis. Functional analysis of the 13 clusters from the gene signature (for full gene list [see Additional file 2b]).

Cluster no.	Top Network overall	Top high level function	Top canonical pathway	Number of focus genes able to be mapped*
79	Cancer Inflammatory disease Cell cycle	Lipid metabolism Molecular transport	cAMP mediated signaling	3
148	Cancer Immune response	Cell cycle	1 carbon pool by folate	28
112	Gene expression	Gene expression Protein synthesis	EGF signaling	10
120	Cell cycle Cellular movement	Cell cycle	G2/M checkpoint	28
375	Cellular movement, inflammatory disease	Carbohydrate metabolism	TGF-beta signaling	4
201	DNA recombination and repair	Cell cycle	G1/S checkpoint	11
521	Cell cycle	Cell cycle	G1/S checkpoint	14
784	Cell death	Cell morphology Cellular development	IL4 signaling	3
859	Gene expression	Cell morphology	None given	4
360	DNA recombination and repair	Cell cycle	None given	6
231	Cell to cell signaling and interaction	Embryonic development	IGF1 pathway	13
110	Cell death Cellular development	Cancer Inflammation	PDGF signaling	14
337	Cell morphology	Cellular function and maintenance	None given	1

* note that clusters (pclust) often contained probe sets that represented the same gene