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. Author manuscript; available in PMC: 2009 Apr 2.
Published in final edited form as: FEBS Lett. 2008 Mar 11;582(7):1147–1150. doi: 10.1016/j.febslet.2008.03.002

Fig. 3.

Fig. 3

S1P receptor inhibition reduces COX-2 upregulation by APN or S1P in cardiac myocytes. (A) S1P receptor-inhibition reduces COX-2 upregulation by S1P. Cardiac myocytes were pretreated with VPC23019 or vehicle for 1 hour prior to incubation with S1P or vehicle for 6 hours. Values are expressed relative to vehicle-treated cultures and reported as means ± SEM. *P<0.05, **P<0.01 (A) n=3 in each group. (B) S1P receptor inhibition reduces COX-2 upregulation by APN in cardiac myocytes. Cardiac myocytes were pretreated with 0.01, 0.1 and 1.0µM VPC23019 or vehicle for 1 hour prior to incubation with APN (30 µg/ml) or vehicle for 18 hours. Values are expressed relative to vehicle-treated cultures and reported as means ± SEM. *P<0.05, **P<0.01, n= 3–8 in each group.