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. Author manuscript; available in PMC: 2008 Jun 9.
Published in final edited form as: Biol Psychiatry. 2007 Dec 11;63(7):650–655. doi: 10.1016/j.biopsych.2007.09.023

Figure 2.

Figure 2

Regional Differences Make New Neurons More Difficult to Find in Neocortex than in Dentate Gyrus. A. The large neocortical volume, large number of pyramidal neurons, and large number of BrdU-labeled non-neurons make new neocortical interneurons difficult to detect and recognize. B. The organization of newborn and mature granule cells in the dentate gyrus, small volume of the granule cell layer, and relatively small number of newborn non-neurons make it easier to detect the same relative number of new neurons (1 new neuron for every 5 mature neurons of the same type, in both A and B). This cartoon under-represents the differences between the two regions in at least two ways. First, the ratio of dentate gyrus new neuron density to neocortical new neuron density is 14:1 in the cartoon and greater than 1000:1 in the rodent brain (see Table 1). Second, the ratio of BrdU-labeled non-neurons to BrdU-labeled neurons is 10:1 in the cartoon (part A) and greater than 200:1 in the rodent neocortex.

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