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. Author manuscript; available in PMC: 2008 Oct 2.
Published in final edited form as: Ann Intern Med. 2007 Oct 2;147(7):441–450. doi: 10.7326/0003-4819-147-7-200710020-00002

Table 2.

C-Statistics (95% CIs) of the Models *

Variable BRCAPRO Yale Myriad NCI† Penn‡ FHAT Finnish
All persons 0.82 (0.81–0.84) 0.71 (0.68–0.74) 0.77 (0.75–0.79) - 0.76 (0.74–0.79) 0.77 (0.75–0.8) 0.78 (0.75–0.8)
High-risk studies§ 0.76 (0.73–0.79) 0.64 (0.61–0.67) 0.71 (0.68–0.74) - 0.73 (0.7–0.76) 0.71 (0.68–0.74) 0.75 (0.73–0.78)
Population-based studies§ 0.85 (0.81–0.88) 0.72 (0.65–0.79) 0.79 (0.72–0.86) - 0.75 (0.69–0.81) 0.79 (0.73–0.85) 0.75 (0.68–0.82)
Not Ashkenazi Jewish∥ 0.84 (0.82–0.86) 0.74 (0.71–0.77) 0.78 (0.75–0.81) - 0.76 (0.74–0.79) 0.8 (0.78–0.83) 0.8 (0.78–0.82)
Ashkenazi Jewish∥ 0.72 (0.67–0.77) 0.63 (0.57–0.69) 0.71 (0.66–0.76) 0.63 (0.57–0.68) 0.73 (0.68–0.79) 0.71 (0.66–0.77) 0.74 (0.68–0.8)
No cancer 0.74 (0.67–0.8) 0.62 (0.55–0.69) 0.73 (0.67–0.8) - 0.79 (0.73–0.85) 0.68 (0.6–0.76) 0.81 (0.75–0.87)
Breast cancer only 0.84 (0.82–0.85) 0.76 (0.73–0.78) 0.76 (0.73–0.79) - 0.74 (0.71–0.77) 0.77 (0.74–0.79) 0.74 (0.72–0.77)
Ovarian cancer only 0.88 (0.84–0.93) 0.8 (0.74–0.87) 0.87 (0.81–0.92) - 0.68 (0.57–0.79) 0.83 (0.76–0.91) 0.82 (0.73–0.91)
Both breast and ovarian cancer 0.86 (0.78–0.94) 0.83 (0.75–0.91) 0.8 (0.7–0.91) - 0.8 (0.71–0.89) 0.78 (0.67–0.89) 0.8 (0.72–0.89)
*

FHAT = family history assessment tool; NCI = National Cancer Institute; Penn = University of Pennsylvania; Yale = Yale University.

†

The NCI model was applied only to families of Ashkenazi ethnicity.

‡

The Penn model predicts BRCA1 mutations only. In the table, its performance in predicting mutations in either gene is evaluated to facilitate comparisons with other models and to capture a common use of the model.

§

The “population-based studies” row includes counselees from Fred Hutchinson Cancer Research Center; Baylor College of Medicine; and University of California, Irvine (Orange County). The remainder of counselees are placed in the “high-risk studies” row.

∥

The “Ashkenazi Jewish” row includes counselees of Ashkenazi ancestry from all centers. The remainder of the counselees are placed in the “not Ashkenazi Jewish” row.