Table 3.

Test Performance Characteristics and Posttest Probabilities for the BRCAPRO Model in 3 Populations^*

Variable	UCI Sample	FHCRC Sample	High-Risk Sample
Overall proportion of individuals testing positive	0.017	0.089	0.279
Sensitivity (95% PI)†	0.429 (0.207–0.656)	0.706 (0.547–0.834)	0.824 (0.786–0.857)
Specificity (95% PI)†	0.934 (0.913–0.950)	0.671 (0.620–0.715)	0.526 (0.499–0.551)
Positive likelihood ratio (95% PI)	6.503 (2.925–10.24)	2.148 (1.682–2.71)	1.739 (1.63–1.87)
Negative likelihood ratio (95% PI)	0.612 (0.372–0.843)	0.438 (0.242–0.669)	0.334 (0.269–0.408)
Positive predictive value (95% PI), n/n (%)‡	6/58 (10.34 [4.435–20.08])	24/139 (17.3 [11.69–24.2])	352/874 (40.3 [37.1–43.6])
Negative predictive value (95% PI), n/n (%)§	737/745 (98.9 [98.0–99.5])	235/245 (95.9 [92.9–97.9])	579/654 (88.5 [85.9–90.8])

^*95% PI = 95% posterior probability regions (obtained by using Jeffrey noninformative priors); FHCRC = Fred Hutchinson Cancer Research Center; UCI = University of California, Irvine (Orange County).

^†For a referral threshold probability of 10%.

^‡Proportion of individuals testing positive among those with probability or score >10%.

^§Proportion of individuals testing negative among those with probability or score ≤10%.