Table 4.

Number of Patients per 1000 Referred for Mutation Testing with Different Threshold Probabilities for Referral in the BRCAPRO Model ^*

Variable	Proportion Positive	Threshold	Mutation-Negative above Threshold	Mutation-Positive above Threshold	Mutation-Positive below Threshold	Mutation-Negative below Threshold	Total
UCI sample	0.017	0.05	80.9	8.7	8.7	901.6	1000
		0.1	64.8	7.5	10	917.8	1000
		0.2	47.3	5	12.5	935.2	1000
FHCRC sample	0.089	0.05	351.6	67.7	20.8	559.9	1000
		0.1	299.5	62.5	26	612	1000
		0.2	242.2	62.5	26	669.3	1000
High-risk sample	0.279	0.05	418.8	241.5	38	301.7	1000
		0.1	341.6	230.4	49.1	378.9	1000
		0.2	264.4	209.4	70	456.2	1000

^*These calculations consider the hypothetical scenario in which individuals are referred for genetic counseling whenever their predicted probability using BRCAPRO exceeds the threshold indicated in the third column. “Positive” and “negative” refer to the results of genetic testing, as described in the Methods section. Counts are rescaled to add up to 1000 for ease of comparison. See Appendix Table 4 and Appendix Table 5 (available at www.annals.org) for actual sample sizes and Appendix Table 6 (available at www.annals.org) for the similar calculations using the other models. FHCRC = Fred Hutchinson Cancer Research Center; UCI = University of California, Irvine (Orange County).