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. Author manuscript; available in PMC: 2008 Jun 9.
Published in final edited form as: Methods Mol Biol. 2007;371:9–19. doi: 10.1007/978-1-59745-361-5_2

Table 2.

Molecular Markers of Aging

Cell line tested Aging
bio-marker		 Description Reference
WI-38, HS74, IMR-90 IGF-1 Senescent cells do not produce mRNA for IGF-1 Ferber et al., 1993 (23)
WI-38 EGF Altered form of EGF produced in senescent cells Carlin et al., 1994 (24)
WI-38 c-fos Repressed in late passage cells Seshadri and Campisi, 1990 (25)
WI-38, IDH4, NHEK, CMV-MJ, HCA2 SA-β-Gal Expressed in senescent cells but not in quiescent or terminally differentiated cells Dimri et al., 1995 (26) Itahana et al. (Chapter 4, this volume)