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Superimposition of the free (blue, four independent copies of the orthorhombic crystal form) and hapten-bound (yellow, four independent copies) 34E4. The complementarity determining regions (CDRs) of the light and heavy chains, which are labeled L1–L3 and H1–H3, respectively, undergo only minor changes upon ligand binding, whereas TrpL91 swings into the binding pocket and serves as surrogate ligand in the apo form.
