Fig. 4.
Effects of prolonged diet delivery of MK-886 on mouse behavior in the forced swimming test. Mice (n = 12) on TD.06348 Harlan-Teklad diet with and without MK-886 were assayed in an automated swim test apparatus after two and three weeks of exposure to this diet. Results are shown as mean ± S.E.M.; open bars = vehicle (Veh), closed bars = MK-886 (MK). (A) basic movements, (B) climbing, (C) rest time. Climbing behavior was significantly increased in mice on a diet supplemented with MK-886 for three weeks compared to mice on a drug-free diet (p<0.05).