TABLE 1.

Hydrogen peroxide and MSB induce metaphase fragility of the RNU2 locus in HT1080 cells

Treatment	% Fragilitya
	Per spread	Per locus
H2O2
0 nM	15	6.5
50 nM	23	12
500 nM	33	17
50 μM	27	13
100 μM	20	9.4
MSB
0 nM	18	8.6
50 nM	25	15
100 nM	29	16
200 nM	31	16
500 nM	36	19
1 μM	28	15
10 μM	36	19
100 μM	35	17

^aPer spread, percentage of nuclei with at least one fragile locus; per locus, percentage of total loci scored as fragile.