TABLE 2.
Metaphase fragility of the RNU2 locus and other loci in BRCA1- and BRCA2-deficient cells
| Cell line (description) | % Fragilitya
|
|||||
|---|---|---|---|---|---|---|
|
RNU2
|
RNU1
|
RN5S
|
||||
| Per spread | Per locus | Per spread | Per locus | Per spread | Per locus | |
| MCF7 (BRCA1 low) | 79 | 41 | 100 | 49 | 73 | 32 |
| HCC1937 (BRCA1 mutant) | 74 | 36 | ND | ND | ND | ND |
| CAPAN-1 (BRCA2 null) | 70 | 23 | 84 | 60 | 76 | 40 |
| GM00739Bhtert (CSB mutant) | 68 | 51 | ND | ND | ND | ND |
| GM00739Bhtert CSBwt F1 (rescued) | 31 | 17 | ND | ND | ND | ND |
| WI38htert | 12 | 6 | ND | ND | ND | ND |
a
Per spread, percentage of nuclei with at least one fragile locus; per locus, percentage of total loci scored as fragile; ND, not determined.