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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Pharmacol Biochem Behav. 2008 Jan 16;89(3):314–323. doi: 10.1016/j.pbb.2008.01.003

Figure 2.

Figure 2

Escalating binge cocaine induces age differences in horizontal activity and experimenter observed behavior in male and female rats. Cocaine (5, 10 and 25 mg/kg) was injected i.p. at hourly intervals. Behavioral observations were made simultaneously with the automated activity measurements. Panels a–f show the temporal patterns of behavior following the cocaine treatments. Ambulations (a–b), fine movements (c–d) and average behavioral rating (e–f) are shown for males (left panels) and females (right panels). Injections were given after times 60, 120, and 180 minutes as denoted by arrows in panels a and b. The frequency of intervals in which animals engaged in stereotypies following each injection are shown in g–h. N=12–15 for each age x sex cohort. * indicates greater response in PN 28 males than older males (P<0.05