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. 2008 Feb;29(1):11–26.

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The contents of articles or advertisements in The Clinical Biochemist – Reviews are not to be construed as official statements, evaluations or endorsements by the AACB, its official bodies or its agents. Statements of opinion in AACB publications are those of the contributors. Print Post Approved - PP255003/01665. Copyright © 2005 The Australasian Association of Clinical Biochemists Inc. No literary matter in The Clinical Biochemist – Reviews is to be reproduced, stored in a retrieval system or transmitted in any form by electronic or mechanical means, photocopying or recording, without permission. Requests to do so should be addressed to the Editor. ISSN 0159 – 8090

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PCSK9 and mutations associated with increased and decreased concentrations of LDL cholesterol. PCSK9 has a 30 amino acid signal sequence (SS), followed by a prodomain (Pro), catalytic domain and C-terminal domain. Reprinted from Trends in Biochemical Sciences, 32, Horton JD, Cohen, JC, Hobbs HH, Molecular biology of PCSK9: its role in LDL metabolism, 71–7, Copyright 2007, with permission from Elsevier.⁵⁴