Table 2.

Dutch Lipid Network clinical criteria for diagnosis of heterozygous familial hypercholesterolaemia.

Criteria		Points
1. Family history
A first degree relative with known:
a) Premature* coronary and vascular disease		1
b) Plasma LDL-C concentration >95th percentile for age and sex
i) In an adult relative		1
ii) In a relative <18 years of age		2
c) Tendon xanthomata or arcus cornealis		2
2. Clinical history
Patient has premature*:
a) Coronary artery disease		2
b) Cerebral or peripheral vascular disease		1
3. Physical examination of the patient
a) Tendon xanthomata		6
b) Arcus cornealis in a patient <45 years of age		4
4. LDL-C levels in patient’s blood (mmol/L)
a)≥8.5		8
b) 6.5–8.4		5
c) 5.0–6.4		3
d) 4.0–4.9		1
5. DNA analysis showing functional mutation in the LDLR or other FH-related gene		8
Interpretation	Diagnosis	Total points
	Definite FH	>8
	Probable FH	6–8
	Possible FH	3–5

^*if male, <55 years; if female, <60 years.

Reprinted with permission from the World Health Organization.³⁴