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Synthesis of piperazinedione-fused tricyclic compounds 3a–d. a) ClCH2COCl (1.5 equiv), Et3N (2.5 equiv), CH2Cl2, 25 °C, 30 min, F-SPE. b) R4NH2 (2.5 equiv), MeOH, μw (120°C, 10 min), F-SPE. c) DBU (2 equiv), MeOH-DMF, μw (180 °C, 15 min), F-SPE, HPLC.
