Table 3.

Mineral Composition of Tibiae from 1-, 2- and 4- month old Outbred and B6 Wt, oim/+ and oim/oim Mice

Mineral (ppm)	Outbred			B6

	Wt	oim/+	oim/oim	Wt	oim/+	oim/oim
1 month

F	101.7±6.8^d ^e	109.3±6.8^d ^e	118.2±10.6^d ^e	124.1±14.8^c ^d ^e	130.7±14.3^d ^e	186.6±10.5^a ^b ^c ^d ^e

P (x1000)	111.5±0.90^d ^e	115.9±1.2^a ^d ^e	114.2±3.0^a ^d ^e	108.4±0.95^e	113.3±1.1^a ^e	118.7±1.3^a ^b ^d ^e

Na (x100)	30.6±0.85^d ^e	29.6±0.88^d ^e	29.3±1.31^d ^e	23.6±0.78^c ^d ^e	24.0±2.2^c ^d ^e	16.2±0.64^b ^c ^d ^e

Mg (x100)	50.6±0.84^d ^e	52.5±0.68^d ^e	54.0±0.83^a ^e	50.2±0.75^e	53.7±0.80^a ^e	56.0±0.89^a ^b

Ca (x1000)	238.9±2.4^e	245.0±3.1^e	246.1±4.4^e	233.0±2.3^e	243.5±1.8^a ^e	211.9±3.3^a ^e

Ca/P Ratio	2.14±0.01^e	2.11±0.01^e	2.16±0.02^d ^e	2.15±0.01^d ^e	2.15±0.02^d	2.06±0.02^a ^b ^c ^d

K	215.4±11.1^e	315.2±58.5^a ^e	472.0±59.1^a ^b ^e	160.1±43.7^d ^e	170.8±20.5^d ^e	82.6±15.3^c ^d ^e

Zn	152.7±17.6^d	179.1±29.7^e	274.0±45.3^a ^b	134.3±15.5^e	188.7±22.6	223.5±26.9^a ^d

2 months

F	134.5±6.9^e	163.0±5.7^a ^e	254.3±31.6^a ^b ^e	232.7±13.1^c	220.4±9.0^c ^e	375.2±16.5^a ^b ^c

P (x1000)	116.4±0.71^e	119.9±0.49^a ^e	121.6±1.6^a ^e	112.5±1.3^e	115.7±1.5^c ^e	123.7±0.93^a ^b ^e

Na (x100)	39.5±0.58^e	40.7±0.47	34.9±0.88^a ^b	38.6±0.58	34.7±0.89^a ^c ^e	29.3±0.68^a ^b ^c ^e

Mg (x100)	46.8±0.45	48.9±0.54	54.4±1.64^a ^b ^e	49.2±0.70^c ^e	51.6±0.63^a ^c	54.4±0.57^a ^b

Ca (x1000)	245.1±1.4^e	251.3±1.1^a ^e	252.0±2.6^a ^e	233.7±2.4^c ^e	238.9±2.9^c ^e	246.9±1.1^a ^b ^e

Ca/P Ratio	2.11±0.01	2.10±0.01	2.07±0.01	2.08±0.03	2.06±0.01^e	2.0±0.01^a ^b ^c ^e

K	224.6±31.7^e	384.8±41.2^a	420.6±65.4^a	366.8±39.6^c	336.4±54.9	241.5±33.8^a ^c

Zn	241.2±20.6	205.2±28.1	335.1±28.2^a ^b	195.4±24.3	185.3±23	296.3±36.4^a ^b

4 months

F	200.1±6.4	237.9±8.1^a	308.1±9.8^a ^b	262.9±11.0^c	283.7±6.4^c	402.5±17.1^a ^b ^c

P (x1000)	126.4±1.0	130.1±0.69	131.2±1.3^a	123.4±2.3	123.9±2.5^c	129.5±1.1^a ^b

Na (x100)	43.0±0.54	40.4±0.78^a	34.8±0.70^a ^b	39.7±0.80^c	38.1±0.82^c	32.8±0.68^a ^b

Mg (x100)	46.3±0.36	48.2±0.55	50.3±0.87^a	45.5±0.74	49.7±1.09^a	54.4±0.54^a ^b ^c

Ca (x1000)	263.7±1.2	269.3±0.7	268.8±1.4	253.9±3.7^c	261.4±5.6^c	268.7±1.1^a ^b

Ca/P Ratio	2.09±0.02	2.07±0.01	2.05±0.01	2.06±0.04	2.11±0.02	2.08±0.01^c

K	356.2±39.5	432.9±55.9	295.9±40.5^b	333.9±55.5	286.2±20.0^c	242.4±28.9

Zn	190.0±22.1	259.7±16.2^a	311.3±26.8^a	208.5±13.9	228.9±18.3	251.8±31.9

p<0.05 compared to Wt of same strain and age

p<0.05 compared to oim/+ of same strain and age

p<0.05 compared to outbred animals of same genotype and age

p<0.05 compared to 2 month animals of same genotype and strain

p<0.05 compared to 4 month animals of same genotype and strain