Table 4.

Cohen's kappa for GIPD total scores (OC) with 95% confidence intervals (CI) over time.

Week	Patient – Parent	Patient – Physician	Physician – Parent
0	0.1615 (0.116;0.207)	0.1420 (0.106;0.178)	0.5212 (0.471;0.572)
1	0.1992 (0.144;0.254)	0.1968 (0.150;0.244)	0.5748 (0.522;0.627)
2	0.2464 (0.189;0.304)	0.2605 (0.206;0.315)	0.6282 (0.581;0.676)
4	0.2318 (0.176;0.288)	0.2790 (0.221;0.337)	0.6198 (0.572;0.667)
6	0.2493 (0.185;0.313)	0.3036 (0.244;0.363)	0.6777 (0.636;0.719)
8	0.3124 (0.239;0.386)	0.3269 (0.258;0.395)	0.6530 (0.606;0.700)
12	0.2287 (0.172;0.286)	0.2361 (0.181;0.291)	0.6373 (0.586;0.689)
16	0.2569 (0.187;0.327)	0.3150 (0.245;0.385)	0.6348 (0.579;0.690)
24	0.2618 (0.196;0.328)	0.3188 (0.253;0.385)	0.6607 (0.609;0.712)

GIPD = Global Impression of Perceived Difficulties; OC = observed cases.