Table 6.
Type and Incidence of Second Cancers Reported in Literature
| Cooperative Group Study or Institution/Registry | Study Period | No. Patients | No. Second Leukemia | No. Second Solid Tumor | CI Second Cancer | Reference |
|---|---|---|---|---|---|---|
| NCI SEER & Connecticut Tumor Registry | 1935–1989 | 595 | 2 | 11 | NR | Travis et at. 199411 |
|
| ||||||
| MD Anderson Cancer Center | 1944–1976 | 173 | 0 | 4 | 35% 10-yr | Strong et al. 19796 |
|
| ||||||
| Stanford University Medical Center | 1960–1986 | 64 | 1 | 1 | 8.4% 5-yr | Smith et al. 199255 |
|
| ||||||
| NCI-PB, St. Jude, & University of Florida Medical School | 1963–1990 | 266 | 2 | 14 | 5% 10-yr
9.2% 20-yr |
Kuttesch et al. 19965 |
|
| ||||||
| Hospital La Fe, Spain | 1970–1995 | 121 | 2 | 2 | NR | Aparicio et al. 199814 |
|
| ||||||
| DFCI & Children’s Hospital in Boston | 1971–1988 | 82 | 1 | 6 | 6.7% 10-yr
42.8% 20 yr |
McLean et al 19998 |
|
| ||||||
| Istituto Ortopedico Rizzoli, Bologne, Italy | 1972–1999 | 597 | 3 | 11 | 3.0% 5-yr
6.5% 10-yr 12.7% 20-yr |
Bacci et al. 20057 |
|
| ||||||
| Istituto Nazionale Tumori, Milan, Italy | 1974–1986 | 121 | 0 | 7 | NR | Gaspirini et al. 199415 |
|
| ||||||
| CESS | 1981–1986 | 674 | 5 | 3 | 0.7% 5-yr
2.9% 10-yr 4.7% 15-yr |
Dunst et al. 199856 |
|
| ||||||
| CCG/POG INT-0091 | 1988–1992 | Bhatia et al. 20079 | ||||
| Regimen A | 262 | 3 | 2 | 0.4% 5-yr | ||
| Regimen B | 256 | 2 | 2 | 0.9% 5-yr | ||
| Regimen C | 60 | 6 | 0 | 11% 5-yr | ||
|
| ||||||
| GPOH | 1992–1999 | 690 | 4 | 2 | 0.9% 5-yr | Paulussen et al. 200110 |
|
| ||||||
| St. Jude Children’s Research Hospital | 1979–2004 | 237 | 8 | 4 | 3.0% 5-yr
4.7% 10-yr |
Navid et al. (Current Study) |
Abbreviations: NR, not reported; NCI SEER, National Cancer Institute’s Surveillance, Epidemiology, and End Results Program; CESS, Cooperative Ewing’s Sarcoma Studies; GPOH, German/Austrian/Dutch Society of Pediatric Oncology and Hematology; CCG/POG Children’s Cancer Group/Pediatric Oncology Group; DFCI, Dana-Farber Cancer Institute; NCI-PB, National Cancer Institute-Pediatric Branch; Cl, cumulative incidence.