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A, Punch samples of freshly-excised human colon tumors (n = 6) and matched normal margin areas, were infected with either ColoAd1 or Ad5 and maintained in tissue culture. The viral burst from each sample was measured by plaque assay at 24 hours post infection. B, Immunohistochemical staining for CD46 present in clinical colon tumor, normal colon, and normal liver samples.
