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. 2008 Jul 18;4(7):e1000103. doi: 10.1371/journal.pcbi.1000103

Figure 1. A Scheme of the Computational Model of HIV/SIV Infection.

Figure 1

A number of n CTL clones can recognize n different epitopes and kill the cells infected with virus expressing those epitopes. The virus population can evade recognition from specific CTL clones by acquiring escape mutations (shown as e). Since escape mutations can be associated with a fitness cost in viral replication or infectivity, the virus additionally acquires compensatory mutations (shown as c) that can partially restore the viral fitness.