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. 2008 Jun 18;3(6):e2493. doi: 10.1371/journal.pone.0002493

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Beer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) A normal adult liver (MYC OFF Adult). (B) An adult liver tumor (MYC ON Adult). (C) A normal 4 w old liver (MYC OFF Neonate). (D) A neonatal liver tumor (MYC ON Neonate). (E) An adult liver 3–4 weeks after continuous DDC treatment (MYC OFF/DDC). (F) An adult liver tumor induced by MYC overexpression in conjunction with continuous DDC treatment (MYC ON/DDC). (G) An adult liver 4 weeks after continuous CCl₄ treatment (MYC OFF/CCl₄). (H) An adult liver tumor induced by MYC overexpression in conjunction with continuous CCl₄ treatment (MYC ON/CCl₄). Representative animals from each cohort are presented. Note that toxin-accelerated HCC are diffuse, similar in appearance to neonatal tumors. In contrast, normal MYC-induced adult tumors present as a distinct, multifocal disease.