Table 2.
Effects of Risk Factors for Pancreatic Adenocarcinoma in Multivariable Logistic Regression Analysis
Patients (N = 808)
|
Controls (N = 808)
|
||||||
---|---|---|---|---|---|---|---|
Study Variables | N | % | N | % | AOR (95% CI)* | ||
Past history of diabetes mellitus | |||||||
Never | 614 | 76.0 | 729 | 90.2 | 1 (reference) | ||
Ever | 194 | 24.0 | 79 | 9.8 | 2.6 (1.9–3.4) | ||
Duration of diabetes, yr | |||||||
≤1 | 76 | 9.4 | 22 | 2.7 | 4.0 (2.5–6.6) | ||
>1 | 118 | 14.6 | 57 | 7.1 | 2.4 (1.7–3.4) | ||
2–5 | 55 | 6.8 | 25 | 3.1 | 2.7 (1.7–4.4) | ||
6–10 | 26 | 3.2 | 10 | 1.2 | 2.8 (1.3–5.9) | ||
>10 | 37 | 4.6 | 22 | 2.7 | 1.9 (1.1–3.3) | ||
Treatment of diabetes mellitus | |||||||
Insulin only | 15 | 1.9 | 3 | 0.4 | 5.9 (1.7–21.1) | ||
Oral only | 82 | 10.2 | 51 | 6.3 | 1.9 (1.3–2.8) | ||
Both | 21 | 2.6 | 3 | 0.4 | 7.1 (2.1–24.4) | ||
Cigarette smoking | |||||||
Never | 323 | 40.0 | 415 | 51.4 | 1 (reference) | ||
Ever | 485 | 60.0 | 393 | 48.6 | 1.6 (1.2–1.9) | ||
Duration of smoking, pack-years | |||||||
≤20 | 199 | 24.6 | 203 | 25.1 | 1.4 (1.1–1.8) | ||
>20 | 286 | 35.4 | 190 | 23.5 | 2.0 (1.6–2.6) | ||
Alcohol consumption | |||||||
Never | 371 | 45.9 | 364 | 45.0 | 1 (reference) | ||
Ever | 437 | 54.1 | 444 | 55.0 | 1.0 (0.8–1.2) | ||
Heavy alcohol drinking† | |||||||
≤60 mL ethanol/day | 355 | 43.9 | 386 | 47.8 | 0.9 (0.7–1.2) | ||
>60 mL ethanol/day | 67 | 8.3 | 42 | 5.2 | 1.6 (1.1–2.5) |
AOR = odds ratio adjusted for age, sex, race/ethnicity, smoking history, diabetes history, heavy alcohol consumption, family history of pancreatic cancer, history of pancreatitis, education level, and state of residency.
Data on duration of drinking were missing for 15 patients and 16 controls.