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. 2008 Jun 12;118(7):2427–2437. doi: 10.1172/JCI35017

Figure 2. Defects in CLL B cells and T cells contribute to decreased immunological synapse formation.

Figure 2

(A) Conjugates from mixed allogeneic experiments using T cells or CLL B cells from leukemic patients with healthy allogeneic cells were selected at random for imaging and scored for accumulation of F-actin (red) at the immune synapse (with or without sAg-pulsed APCs, blue). As controls, healthy T cells were conjugated with allogeneic healthy B cells. Data are the mean ± SD from 6 independent experiments, with 50 conjugates analyzed per experiment. (B) T cell conjugates from mixed allogeneic experiments (sAg-pulsed CLL B or healthy B cells, blue) were scored by visual counting using a confocal microscope. Each data set shows the mean ± SD from 6 independent experiments, with 50 random T cells analyzed per experiment. Original magnification, ×63.