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The plasma concentration–time curves for phentolamine following the administration of phentolamine 0.4 mg intravenously (1Piv; closed triangle), phentolamine 0.4 mg submucosally (1L1P; closed circle), and phentolamine 0.8 mg submucosally (4L2P; open square). Lidocaine (LA) was administered 30 minutes (−0.5 hours) prior to phentolamine administration (T0 hours).
