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. 2008 May 28;4:18. doi: 10.1186/1744-8069-4-18

Figure 2.

Figure 2

Signalling pathways underlying the induction of LFS-induced LTP in vivo. In all graphs, area of C-fibre evoked field potentials (% of control) is plotted against time (min). Data are expressed as mean ± SEM (n = 5 for all groups). Spinal superfusion at the recording segment with the T-type VDCC blocker mibefradil (5 mM, A), the ryanodine receptor blocker dantrolene (500 μM, C), the PLC inhibitor U-73122 (500 μM, D), the PKC blocker chelerythrine (800 μM, E), the NMDA receptor blocker D-AP5 (100 μM, F) or the CaMKII blocker KN-93 (400 μM, G) fully blocked LTP induction by LFS. Blockade of spinal NK1 receptors with L-703,606 led to induction of LTD rather than LTP by LFS (B). See also Table 1.