Table 1.
Pharmacokinetic properties of fluvoxamine
| Oral absorption | ≥ 94% |
| Cmax | 31–87 mg/L |
| Tmax | 2–8 hours |
| Time to reach steady-state | ≈ 10 days |
| Absolute bioavailability | ≈ 50% |
| AUC | 927 μg/L~hour |
| Vd | 25 L/kg |
| Plasma protein binding | ≈ 77% |
| t½β | 15 hours after a single dose |
| Route of metabolism | Hepatic oxidation |
| Route of excretion | Urine |
Data adapted from van Harten (1995).
Abbreviations: Cmax, maximum plasma concentration; Tmax, time to maximum plasma concentration; AUC, area under the plasma concentration-time curve; Vd, volume of distribution; t½β, terminal elimination half-life.