Table 3.

Frequencies and odds ratios of chronic medical conditions and adverse health status in siblings, all ALL survivors, and nonrelapsed, nonirradiated survivors (restricted to those age 18 years and older)

Outcome	Siblings, n (%)	All ALL survivors, n (%)	OR for all ALL survivors vs siblings (95% CI) †	P	Nonrelapsed, nonirradiated survivors, n (%)	OR for nonrelapsed, nonirradiated survivors vs siblings (95% CI)†	P
Number in each group	3083	2599			426
Chronic medical conditions
Hearing	12 (0.4)	27 (1.0)	3.0 (1.5-6.8)	<.001	4 (0.9)	2.7 (0.5-7.8)	.17
Vision	21 (0.7)	30 (1.2)	1.6 (0.9-3.1)	.19	2 (0.5)	0.5 (0.1-1.6)	.26
Endocrine	56 (1.8)	114 (4.4)	3.1 (2.3-4.5)	<.001	5 (1.2)	1.0 (0.2-2.2)	.96
Pulmonary	37 (1.2)	78 (3.0)	4.2 (2.8-6.6)	<.001	8 (1.9)	2.7 (1.0-5.1)	.05
Cardiac	21 (0.7)	82 (3.2)	6.9 (4.212.9)	<.001	6 (1.4)	3.8 (0.9-10.0)	.06
Gastrointestinal	14 (0.5)	18 (0.7)	2.2 (1.0-5.0)	.04	1 (0.2)	1.0 (0.2-5.7)	.96
Renal	5 (0.2)	21 (0.8)	4.8 (2.118.9)	<.001	2 (0.5)	4.1 (0.5-37.0)	.29
Musculoskeletal	3 (0.1)	14 (0.5)	7.7 (2.821.3)	<.001	4 (0.9)	22.8 (4.0-128.1)	.03
Neurologic	13 (0.4)	62 (2.4)	5.3 (3.111.4)	<.001	3 (0.7)	1.6 (0.5-5.4)	.49
Grade 3 to 4	179 (5.8)	382 (14.7)	3.7 (3.0-4.5)	<.001	34 (8.0)	2.0 (1.3-3.0)	.01
2 or more in grades 1 to 4	433 (14.0)	667 (25.7)	2.8 (2.4-3.2)	<.001	73 (17.1)	1.9 (1.4-2.5)	<.001
Adverse health status
General health	157 (5.1)	230 (8.9)	2.1 (1.6-2.7)	<.001	24 (5.6)	1.2 (0.7-1.9)	.45
Mental health	302 (9.8)	389 (15.0)	1.7 (1.4-2.0)	<.001	61 (14.3)	1.6 (1.1-2.1)	.01
Activity limitation	178 (5.8)	230 (8.9)	1.8 (1.5-2.3)	<.001	28 (6.6)	1.3 (0.8-2.0)	.25
Functional impairment	79 (2.6)	227 (8.7)	4.1 (3.1-5.6)	<.001	18 (4.2)	2.0 (1.0-3.3)	.05

CI indicates confidence interval.

* Adjusted for age at interview, sex, and ethnicity.

^†Adjusted for cumulative anthracycline dose, alkylator score, age at interview, age at diagnosis, sex, and ethnicity.