Table 4.
Frequencies and odds ratios of chronic medical conditions and adverse health status in nonrelapsed, relapsed, nonirradiated and irradiated survivors (restricted to those age 18 years and older)
| Outcome | Nonrelapsed survivors, n (%) | Relapsed survivors, n (%) | OR for relapsed versus nonrelapsed survivors (95% CI)* | P | Nonirradiated survivors, n (%) | Irradiated survivors, n (%) | OR for irradiated versus nonirradiated survivors† (95% CI) | P |
|---|---|---|---|---|---|---|---|---|
| No. in each group | 2222 | 377 | 451 | 1770 | ||||
| Chronic medical conditions | ||||||||
| Hearing | 20 (0.9) | 7 (1.9) | 2.3 (0.9-5.7) | .09 | 4 (0.9) | 22 (1.2) | 1.1 (0.4-3.4) | .88 |
| Vision | 21 (1.0) | 9 (2.4) | 3.3 (1.4-7.9) | .006 | 4 (0.9) | 23 (1.3) | 1.4 (0.4-4.2) | .61 |
| Endocrine | 71 (3.2) | 43 (11.4) | 5.4 (3.4-8.6) | <.001 | 6 (1.3) | 90 (5.1) | 4.1 (1.6-10.4) | .003 |
| Pulmonary | 59 (2.7) | 19 (5.0) | 1.8 (1.0-3.4) | .06 | 13 (2.9) | 59 (3.3) | 1.2 (0.6-2.5) | .53 |
| Cardiac | 54 (2.4) | 28 (7.4) | 2.8 (1.5-4.9) | <.001 | 10 (2.2) | 59 (3.3) | 1.6 (0.8-3.3) | .22 |
| Gastrointestinal | 14 (0.6) | 4 (1.1) | 1.5 (0.4-5.3) | .53 | 2 (0.4) | 16 (0.9) | 1.9 (0.4-8.5) | .42 |
| Renal | 11 (0.5) | 10 (2.7) | 5.2 (2.0-13.8) | <.001 | 3 (0.7) | 16 (0.9) | 1.4 (0.4-5.0) | .59 |
| Musculoskeletal | 11 (0.5) | 3 (0.8) | 1.3 (0.4-5.0) | .68 | 4 (0.9) | 10 (0.6) | 0.6 (0.2-2.2) | .46 |
| Neurologic | 40 (1.8) | 22 (5.8) | 3.2 (1.7-6.2) | <.001 | 6 (1.3) | 46 (2.6) | 1.6 (0.6-3.8) | .34 |
| Grade 3 to 4 | 268 (12.1) | 114 (30.2) | 3.4 (2.5-4.5) | <.001 | 46 (10.2) | 291 (16.4) | 1.7 (1.2-2.4) | .005 |
| 2 or more in grades 1 to 4 | 492 (22.1) | 175 (46.4) | 3.0 (2.3-3.9) | <.001 | 86 (19.1) | 479 (27.1) | 1.5 (1.1-2.0) | .005 |
| Adverse health status | ||||||||
| General health | 190 (8.6) | 40 (10.6) | 1.7 (1.1-2.6) | .01 | 30 (6.7) | 162 (9.2) | 1.4 (0.9-2.2) | .12 |
| Mental health | 334 (15.0) | 55 (14.6) | 1.1 (0.8-1.6) | .62 | 66 (14.6) | 276 (15.6) | 1.0 (0.7-1.3) | .86 |
| Activity limitation | 169 (7.6) | 61 (16.2) | 2.5 (1.7-3.7) | <.001 | 32 (7.1) | 164 (9.3) | 1.5 (1.0-2.3) | .07 |
| Functional impairment | 186 (8.4) | 41 (10.9) | 1.7 (1.1-2.5) | .02 | 23 (5.1) | 173 (9.8) | 2.2 (1.4-3.5) | .001 |
CI indicates confidence interval.
*
Adjusted for age at interview, age at diagnosis, sex, and ethnicity.
†
Adjusted for cumulative anthracycline dose, alkylator score, age at interview, age at diagnosis, sex, and ethnicity.