. Author manuscript; available in PMC: 2008 Jun 11.

Published in final edited form as: Arch Intern Med. 2007 Aug 13;167(15):1648–1653. doi: 10.1001/archinte.167.15.1648

Table 4.

Cox Multivariable Regression Models Examining Sex Differences in the Association Between Amiodarone Use and Risk of Permanent Pacemaker Insertion

Models^a	HR (95% CI)^b	P Value
Effect of amiodarone use^c
Women	4.69 (1.99–11.05)	<.001
Men	1.05 (0.42–2.58)	.92
Effect of amiodarone dose^d
Women (doses ≤200 mg)	3.89 (1.39–10.88)	<.01
Women (doses >200 mg)	5.73 (2.12–15.47)	<.001
Men (doses ≤200 mg)	0.83 (0.27–2.58)	.75
Men (doses >200 mg)	1.23 (0.46–3.27)	.68

Abbreviations: CI, confidence interval; HR, hazard ratio.

Separate models were used to examine sex differences in the effects of amiodarone use and amiodarone dose (daily doses >200 mg vs ≤200 mg) on the risk of permanent pacemaker insertion.

The HRs and the 95% CIs have been adjusted for age, atrial flutter, coronary artery disease, heart failure, and hypertension.

The interaction between sex and amiodarone use was statistically significant (P = .02).

The interaction between sex and amiodarone remained statistically significant after adjustment for amiodarone dose (P = .02). The interaction between amiodarone dose and amiodarone use (ie, the difference between daily doses >200 mg vs ≤200 mg) was not statistically significant (P = .48).